Foxsports.com reported Monday that DeRosa, who is coming off his best season in which he batted .287 and set personal bests with 21 home runs and 87 RBIs, will join Boston's Dustin Pedroia at second base for the U.S. team.
In the World Baseball Classic's inaugural season in 2006, first baseman Derrek Lee and catcher Michael Barrett both represented the Cubs on Team USA.
DeRosa, 33, also can play third, short and the corner outfield spots. Over 11 Major League seasons, he has compiled a .279 average with 69 homers and 352 RBIs in 893 games.
On Monday, Mets third baseman David Wright also committed to play for Team USA at the World Baseball Classic, which runs from March 5-23.
DeRosa is expected to join Team USA for its workouts March 2 in Clearwater, Fla. The first game is scheduled for March 7 against Team Canada. Italy and Venezuela are in the same pool as Team USA.
Other Cubs who may play in the World Baseball Classic include outfielder Kosuke Fukudome (Japan) and Carlos Zambrano (Venezuela). Geovany Soto has expressed a desire to play for the Puerto Rico team but may be bumped because of the number of catchers on the squad, including Yadier Molina and Ivan Rodriguez.
Carrie Muskat is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.