Cubs starter Scott Feldman was less effective, allowing four runs on six hits and a walk while striking out one over two innings and two batters.
"If you're going to have an outing like today, it's a good thing to have it in spring and not the regular season," Feldman said. "It's an opportunity to kind of sit back and look at things and what I need to work on and make a little bit of adjustment. From where I am right now, second start of spring, I'm just happy I feel good and my fastball is where it needs to be."
In the first game the Cubs have played without a designated hitter, Feldman recorded their only hit through the first four innings, a single to right to end Francis' streak of eight straight outs.
The Rockies tagged Feldman for runs in each of three frames, starting in the first when Todd Helton bounced a double over the wall in the left-field corner after a gritty at-bat, scorching foul balls down the right-field line and into the stands. Helton's first hit of the Cactus League season plated Josh Rutledge, who started the rally with a single to center.
Colorado added on in the second with a one-out double to right from Kent Matthes and a run-scoring single to center from Dexter Folwer.
Wilin Rosario capped Feldman's damage with a two-run homer to center -- his first -- following Troy Tulowitzki's leadoff single in the third, bringing an end to Feldman's outing.
Chicago broke through against Danny Rosenbaum when Edwin Maysonet drove a ball of the wall in the left-center gap, legging it out for an inside-the-park home run as left fielder Tim Wheeler and Fowler scrambled for the ball.
Up next: Lefty Hisanori Takahashi, competing for a spot in the bullpen, will start on Wednesday when the Cubs travel to Surprise, Ariz., to face the Rangers. Takahashi has appeared in three games in relief so far this spring, giving up one run on three hits over four innings. Junior Lake will start in center field and Javier Baez at shortstop. If you get to Surprise early, Jeff Samardzija will be pitching against the Rangers in a "B" game at 10 a.m. MT. The game will be available on an audio broadcast on Cubs.com.
Owen Perkins is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.